I am having the same problem
I had completed approx. 70% of the game (including most sub-missions) and was halfway through The Job mission when I failed it.
A few days later, I reloaded my game which was saved before The Job, get into the car, and I get the Unhandled Exception error when I am heading west over the Starfish Island bridge, going towards Cherry Poppers.
I tried playing without loading any mission, and get the same error in the same spot during general play.
I tried loading an older save game well before The Job, same error, same place.
I deleted the .set file, re-installed the game - still same error.
I can drive around almost anywhere else - but as soon as I am close to Cherry Poppers, the game crashes.
I have no mods installed, and have not used any cheats.
Does anyone have any clue as to what the problem is?
NB: There are two Unhandled Exceptions I am aware of. This specific one (005c2d01) and another beginning with 006. I know how to fix the latter, just not the former