[lil weasel]

Most useful Weapons:
[1] Desert Eagle: One shot One kill, excellent range.
[2] M4 Assault Rifle: 50 rounds, range exceeds AK47 (in game).
[3a] Missile Launcher (Heat Seeking) especially for the Interdiction Mission and Pier 69, also Gang Wars. Anti-Aircraft.
[3b] Missile Launcher (RPG): Blast radius ‘shoots around corner’, through walls, decks, hedges. excellent range.
[4] Molotov cocktails: mass killings, through walls, decks, hedges. Close range. Doesn’t affect CJ.
[5] Any SMG: As it’s used only on Motorcycle during Gang Wars.

That’s all anyone needs. Unless you’re just fooling around and want to get CJ killed.

[Fisciletti]

Here are my favourites, in order from slot 1 to slot 11:

• Brass Knuckles
  
• Katana
  
• Desert Eagle
  
• Combat Shotgun
  
• MP5
  
• AK-47
  
• Sniper Rifle
  
• Molotov cocktail
  
• Minigun
  
• Spray painter
  
• Flowers

[pawlowskinz]

M4 tops them all. No gun seems better other than the mini-gun.

[arijitsen]

My favourite weapons...

Slot 1:
Brass Knuckle

Slot 2:
Chainsaw

Slot 3:
Silenced 9mm

Slot 4:
Combat shotgun

Slot 5:
mp5

Slot 6:
M4

Slot 7:
Sniper rifle

Slot 8:
Grenade

Slot 9:
Minigun

Slot 10:
Camera

Slot 11
Flowers

[aritrabose]

Minigun, Smg,M4, Sniper rifle, combat shotgun.