I think BS and Ryder would win personally. Throughout the entire game, CJ is trying to take them both down.
They basically send Carl on a wild goose chase across the state. Lucky for CJ, he killed them separately- I think if Carl hunted down BS and Ryder and they attempted to kill him w/ Sweet, BS and Ryder would win. They have so much more power.
Didn't the game pretty much settle this? I mean, yeah, Smoke was a handful, but Ryder? He ran away, and even then CJ managed to kill him fairly easily. CJ on his own might be able to handle them, but with Sweet as well, it seems like no contest.